Welcome to Ant Larva

BACKGROUND: Our aim was to investigate postoperative complications and mortality after administration of aprotinin compared to tranexamic acid in an unselected, consecutive cohort.

METHODS: Perioperative data from consecutive cardiac surgery patients were prospectively collected between September 2005 and June 2006 in a university-affiliated clinic (n = 1188). During the first 5 mo, 596 patients received aprotinin (Group A); in the next 5 mo, 592 patients were treated with tranexamic acid (Group T). Except for antifibrinolytic therapy, the anesthetic and surgical protocols remained unchanged.

RESULTS: The pre- and intraoperative variables were comparable between the treatment groups. Postoperatively, a significantly higher incidence of seizures was found in Group T (4.6% vs 1.2%, P < 0.001). This difference was also significant in the primary valve surgery and the high risk surgery subgroups (7.9% vs 1.2%, P = 0.003; 7.3% vs 2.4%, P = 0.035, respectively). Persistent atrial fibrillation (7.9% vs 2.3%, P = 0.020) and renal failure (9.7% vs 1.7%, P = 0.002) were also more common in Group T, in the primary valve surgery subgroup. On the contrary, among primary coronary artery bypass surgery patients, there were more acute myocardial infarctions and renal dysfunction in Group A (5.8% vs 2.0%, P = 0.027; 22.5% vs 15.2%, P = 0.036, respectively). The 1-yr mortality was significantly higher after aprotinin treatment in the high risk surgery group (17.7% vs 9.8%, P = 0.034).

CONCLUSION: Both antifibrinolytic drugs bear the risk of adverse outcome depending on the type of cardiac surgery. Administration of aprotinin should be avoided in coronary artery bypass graft and high risk patients, whereas administration of tranexamic acid is not recommended in valve surgery.

Meta Math! The Quest for Omega
Written by Gregory Chaitin

In Meta Math!, Gregory Chaitin, one of the world’s foremost mathematicians, leads us on a spellbinding journey of scientific discovery and illuminates the process by which he arrived at his groundbreaking theories.

All of science is based on mathematics, but mathematicians have become painfully aware that math itself has serious limitations. This notion was first revealed in the work of two giants of twentieth-century mathematics: Kurt Gödel and Alan Turing. Now their successor, Gregory Chaitin, digs even deeper into the foundations of mathematics, demonstrating that mathematics is riddled with randomness, enigmas, and paradoxes.

Chaitin’s revolutionary discovery, the Omega number, is an exquisitely complex representation of unknowability in mathematics. His investigations shed light on what, ultimately, we can know about the universe and the very nature of life. But if unknowability is at the core of Chaitin’s theories, the great gift of his book is its completely engaging knowability. In an infectious and enthusiastic narrative, Chaitin introduces us to his passion for mathematics at its deepest and most philosophical level, and delineates the specific intellectual and intuitive steps he took toward the discovery of Omega. In the final analysis, he shows us that mathematics is as much art as logic, as much experimental science as pure reasoning. And by the end, he has helped us to see and appreciate the art––and the sheer beauty––in the science of math.

In Meta Math!, Gregory Chaitin takes us to the very frontiers of scientific thinking. It is a thrilling ride.


From the Hardcover edition.